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AKA-25
Betuak® Betulinic Acid
Cat. No.
AKA-25
CAS No.
472-15-1
MF
C30H48O3
MW
456.7003
Betuak® Betulinic acid is a natural pentacyclic lupane-type triterpene, an inhibitor of eukaryotic topoisomerase I.
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Technical Data
Description
Storage and Shipping
References
Product Name
Betuak® Betulinic Acid
CAS No.
472-15-1
MF
C30H48O3
MW
456.7003
Specification
98%
Research Area
Antiretroviral, antimalarial, and anti-inflammatory
Description
Betuak® Betulinic acid is a natural pentacyclic lupane-type triterpene, an inhibitor of eukaryotic topoisomerase I. Packing: 1kg/bag; 25kg/drum or as request Availability: In stock
Documents
Certificate of Analysis (COA), API specification, Safety Data Sheet (SDS/MSDS), evidence of GMP compliance, Stability data / Stability summary, etc.
Storage and Shipping
Store in a cool & dry place, keep away from strong light and heat.
References
[1]. Chowdhury AR, et al. Betulinic acid, a potent inhibitor of eukaryotic topoisomerase I: identification of the inhibitory step, the major functional group responsible and development of more potent derivatives. Medical Science Monitor. 2002 Jul;8(7):BR254-65.
[2]. Gao Y, et al. Betulinic acid induces apoptosis and ultrastructural changes in MDA-MB-231 breast cancer cells. Ultrastructural Pathology. 2018 Jan-Feb;42(1):49-54.
[3]. Kalra J, et al. Betulinic acid alleviates dextran sulfate sodium-induced colitis and visceral pain in mice. Naunyn-Schmiedeberg's Archives of Pharmacology. 2017 Dec 26.
[4]. Hashimoto F, et al. Anti-AIDS agents--XXVII. Synthesis and anti-HIV activity of betulinic acid and dihydrobetulinic acid derivatives. Bioorganic & Medicinal Chemistry. 1997 Dec;5(12):2133-43.
[5]. Kasperczyk H, et al. Betulinic acid as new activator of NF-kappaB: molecular mechanisms and implications for cancer therapy. Oncogene. 2005 Oct 20;24(46):6945-56.
[6]. Fernandes S, et al. Betulinic Acid for Glioblastoma Treatment: Reality, Challenges and Perspectives. International Journal of Molecular Sciences. 2024 Feb 9;25(4):2108.
[2]. Gao Y, et al. Betulinic acid induces apoptosis and ultrastructural changes in MDA-MB-231 breast cancer cells. Ultrastructural Pathology. 2018 Jan-Feb;42(1):49-54.
[3]. Kalra J, et al. Betulinic acid alleviates dextran sulfate sodium-induced colitis and visceral pain in mice. Naunyn-Schmiedeberg's Archives of Pharmacology. 2017 Dec 26.
[4]. Hashimoto F, et al. Anti-AIDS agents--XXVII. Synthesis and anti-HIV activity of betulinic acid and dihydrobetulinic acid derivatives. Bioorganic & Medicinal Chemistry. 1997 Dec;5(12):2133-43.
[5]. Kasperczyk H, et al. Betulinic acid as new activator of NF-kappaB: molecular mechanisms and implications for cancer therapy. Oncogene. 2005 Oct 20;24(46):6945-56.
[6]. Fernandes S, et al. Betulinic Acid for Glioblastoma Treatment: Reality, Challenges and Perspectives. International Journal of Molecular Sciences. 2024 Feb 9;25(4):2108.
Disclaimer
This product is intended solely for scientific research or regulatory filing purposes. We do not provide products or services to individuals, please strictly comply with all applicable laws, regulations, and the committed use. Use for any other purpose is strictly prohibited.
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