Phorbol 12-myristate 13-Acetate
APC-964
Phorbol 12-myristate 13-Acetate
Cat. No.
APC-964
CAS No.
16561-29-8
MF
C36H56O8
MW
616.8
Phorbol 12-myristate 13-Acetate is a phorbol ester, is a dual SphK and protein kinase C (PKC) activator.Phorbol 12-myristate 13-Acetate is also a NF-κB activator.
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Description
Storage and Shipping
References
Product Name
CAS No.
16561-29-8
MF
C36H56O8
MW
616.8
Specification
98%
Research Area
Cell differentiation induction and immune regulation
Description
Phorbol 12-myristate 13-Acetate is a phorbol ester, is a dual SphK and protein kinase C (PKC) activator.Phorbol 12-myristate 13-Acetate is also a NF-κB activator. Packing: 10mg, 20mg, 50mg, 100mg, 500mg, 1g, 5g, 10g Availability: In stock
Storage and Shipping
Store under frozen or refrigerated conditions, keep away from strong light and heat
References
[1]. Sergio E. Alvarez, et al. Autocrine and paracrine roles of sphingosine-1-phosphate. TRENDS in Endocrinology and Metabolism Vol.18 No.8
[2]. Zhang T, et al. MPTP-Induced Depletion in Basolateral Amygdala via Decrease of D2R Activation Suppresses GABAA Receptors Expression and LTD Induction Leading to Anxiety-Like Behaviors. Front Mol Neurosci. 2017 Aug 7;10:247.
[3]. Schwende H, et al. Differences in the state of differentiation of THP-1 cells induced by phorbol ester and 1,25-dihydroxyvitamin D3. J Leukoc Biol. 1996;59(4):555-561.
[4]. Mugami S, et al. Differential roles of PKC isoforms (PKCs) and Ca2+ in GnRH and phorbol 12-myristate 13-acetate (PMA) stimulation of p38MAPK phosphorylation in immortalized gonadotrope cells. Mol Cell Endocrinol. 2017 Jan 5;439:141-154.
[5]. Starr T, et al. The phorbol 12-myristate-13-acetate differentiation protocol is critical to the interaction of THP-1 macrophages with Salmonella Typhimurium. PLoS One. 2018;13(3):e0193601. Published 2018 Mar 14.
Disclaimer
This product is intended solely for scientific research or regulatory filing purposes. We do not provide products or services to individuals, please strictly comply with all applicable laws, regulations, and the committed use. Use for any other purpose is strictly prohibited.
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