APC-755
Forskolin

Cat. No.

APC-755

CAS No.

66575-29-9

MF

C22H34O7

MW

410.5

Forskolin is a potent adenylate cyclase activator, also an inducer of intracellular cAMP formation.
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1g 98% In Stock
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Description
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References
Product Name
Forskolin
CAS No.
66575-29-9
MF
C22H34O7
MW
410.5
Specification
98%
Research Area
Cardiotonic (inotropic), antiplatelet, antihypertensive
Description
Forskolin is a potent adenylate cyclase activator, also an inducer of intracellular cAMP formation.
Packing: 10mg, 20mg, 50mg, 100mg, 500mg, 1g, 5g, 10g
Availability: In stock
Storage and Shipping
Store under frozen or refrigerated conditions, keep away from strong light and heat.
References
[1]. Robbins JD, et al. Forskolin carbamates: binding and activation studies with type I adenylyl cyclase. J Med Chem. 1996 Jul 5;39(14):2745-52. [2]. Matsumiya W, et al. Forskolin modifies retinal vascular development in Mrp4-knockout mice. Invest Ophthalmol Vis Sci. 2012 Dec 7;53(13):8029-35. [3]. Mayati A, et al. Functional polarization of human hepatoma HepaRG cells in response to forskolin. Sci Rep. 2018 Oct 31;8(1):16115. [4]. Awad JA, et al. Interactions of forskolin and adenylate cyclase. Effects on substrate kinetics and protection against inactivation by heat and N-ethylmaleimide. J Biol Chem. 1983 Mar 10;258(5):2960-5. [5]. Seamon KB, et al. Structure-activity relationships for activation of adenylate cyclase by the diterpene forskolin and its derivatives. J Med Chem. 1983 Mar;26(3):436-9. [6]. Ríos-Silva M, et al. Effect of chronic administration of forskolin on glycemia and oxidative stress in rats with and without experimental diabetes. Int J Med Sci. 2014 Mar 11;11(5):448-52. [7]. Rodriguez G, et al. Forskolin-inducible cAMP pathway negatively regulates T-cell proliferation by uncoupling the interleukin-2 receptor complex. J Biol Chem. 2013 Mar 8;288(10):7137-46. [8]. Amrita Datta, et al. High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer. Sci Rep. 2018 May 25;8(1):8161.
Disclaimer
This product is intended solely for scientific research or regulatory filing purposes. We do not provide products or services to individuals, please strictly comply with all applicable laws, regulations, and the committed use. Use for any other purpose is strictly prohibited.
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