Welcome to the News Center, please read the latest news and activities of Aktin.
High-quality intermediates lay the foundation for successful API development and commercial manufacturing. Poor impurity profiles, inconsistent critical quality attributes, or insufficient batch-to-batch consistency often lead to failed downstream reactions, low purification yields, and compromised quality of the final API and drug product.
AkTilin™ is AKTINPHARM®’s dedicated intermediate product line developed for pharmaceutical enterprises, biotechnology companies, and Marketing Authorization Holders (MAHs). Rather than merely delivering pharmaceutical intermediates that meet the required quality specifications, we dive deep into synthetic-route chemistry, process control, impurity profiles, and quality research to deliver intermediates with well-defined impurity profiles, fully characterized structures, stable physical properties, and excellent batch-to-batch reproducibility tailored for subsequent API workflows.
Supported by three proprietary platforms — Phytopower® Development Platform of Bioactive Molecules & Ingredients from Global Medicinal Plants, Aktinsyn® Technology Platform of Synthetic Chemistry, and Aktinbio® Development Platform of Biotechnology—and integrated with our R&D and manufacturing infrastructure and CRDMO capabilities, AkTilin ™ covers the full project lifecycle from early development through to commercialization.
Why Work with AkTilin™ ？
Process Understanding: Robust, scalable synthetic routes established through process research and route evaluation, optimized for safety, quality, and manufacturing efficiency.
Consistent Quality: Management of critical quality attributes via analytical control systems and systematic impurity profiling to ensure batch-to-batch consistency.
Scalable Supply: Transition from laboratory development, process optimization, and pilot scale-up to commercial-scale manufacturing supported by our technical infrastructure, maintaining quality consistency across various production scales to meet material requirements at different project phases.
Technical Partnership: Access to process R&D, analytical, and manufacturing teams to provide technical support throughout the duration of API development projects.
Connected Development Support: From Intermediate to API
AkTilin ™ intermediates are integrated with the broader AKTINPHARM® pharmaceutical development and manufacturing platform to support process transitions from intermediate scale-up through to commercial API production:
Route Screening: Identification and evaluation of practical synthetic pathways with consideration of quality, cost, safety, environmental impact, and scale-up potential to establish chemical routes suitable for R&D and commercial manufacturing.
Process Development: Optimization of reaction conditions, raw materials, process parameters, work-up, and purification protocols to establish reproducible manufacturing processes with scale-up potential.
Impurity Understanding: Characterization, isolation, and control of process-related impurities to ensure intermediate quality satisfies downstream API development and quality control requirements.
Scale-Up & Technical Transfer: Stepwise translation of chemical processes from laboratory development to pilot and commercial-scale manufacturing through technical transfer protocols and parameter optimization.
Analytical Support: Development of analytical methods, testing validation, and quality research supporting both intermediates and APIs.
Commercial Manufacturing: Flexible manufacturing capacity designed to support customer project milestones as pipelines progress from development to commercial volume requirements.
Production Capacity & Lifecycle Support: From R&D to Commercialization
• R&D Centers: Dedicated to the isolation, purification, and structural studies of natural active ingredients, process route exploration and technical evaluation, analytical method development and quality research, API & formulation CRO services, as well as active compound discovery and compound library construction—laying a solid research foundation for API development.
• Non-GMP Facility: Focuses on process route exploration, route optimization, and non-GMP scaling-up, supplying high-quality samples for preclinical and R&D stages to meet the need for speed and flexibility in early-phase drug development.
• GMP Facility: Powered by a comprehensive QC/QA quality management system to achieve commercial manufacturing of APIs and pharmaceutical intermediates , alongside full CRDMO services for both innovative and generic drugs.
AkTilin ™ Intermediates
Therapeutic Area / Chemical Name of Intermediate / CAS No. / Corresponding API
Oncology & Anticancer / 1,4-Diazaspiro[5.5]undecan-3-one / 1547757-91-4 / Trilaciclib
Oncology & Anticancer / (3-Chloro-6-methoxybenzo[b]thiophen-2-yl)(4-fluoro-2,6-dimethylphenyl)methanone / 2088501-19-1 / Rintodestrant
Oncology & Anticancer / (R)-2-(1-Aminoethyl)-4-fluorophenol hydrochloride / 1802222-53-2 / Repotrectinib
Oncology & Anticancer / (R)-tert-Butyl 5-methyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide / 863453-61-6 / Osimertinib
Oncology & Anticancer / 2,4-Dichloropyrimidine / 3934-20-1 / Osimertinib
Oncology & Anticancer / 1-Methylindole / 603-76-9 / —
Oncology & Anticancer / 1-(Tetrahydro-2H-pyran-4-yl)ethanone / 4-Acetyltetrahydropyran / 137052-08-5 / Venetoclax
Oncology & Anticancer / (S)-3-Amino-3-(4-chlorophenyl)propan-1-ol / 886061-26-3 / Capivasertib
Oncology & Anticancer / (S)-1-[6-(4-Fluoro-1H-pyrazol-1-yl)pyridin-3-yl]ethanamine / 1980023-96-8 / Pralsetinib
Oncology & Anticancer / (7S,11R)-5-Hydroxy-4-methyl-10,11-dihydro-6H-7,11-epimino[1,3]dioxolo[4′,5′:5,6]benzo[1,2-d]oxocin-8(7H)-one (Corey 4) / 182201-52-1 / Trabectedin
Oncology & Anticancer / 2-Chloro-4-(1-isopropyl-1H-pyrazol-4-yl)-5-methylpyrimidine / 2387765-45-7 / Flonoltinib Maleate
Oncology & Anticancer / N-Fmoc-3-(3-pyridyl)-L-alanine / 175453-07-3 / Degarelix Acetate
Oncology & Anticancer / (S)-1-Boc-3-methylpiperazine / 147081-29-6 / Sotorasib
Prostate Cancer / 3-Fluoro-4-isothiocyanato-2-(trifluoromethyl)benzonitrile / 1311158-94-7 / Proxalutamide
Prostate Cancer / 4-Isothiocyanato-2-(trifluoromethyl)benzonitrile / 143782-23-4 / Enzalutamide
Prostate Cancer / 4-Bromo-2-fluorobenzoic acid / 112704-79-7 / —
Prostate Cancer / 1-Aminocyclobutane-1-carboxylic acid / 22264-50-2 / Apalutamide
Prostate Cancer / 5-Isothiocyanato-3-(trifluoromethyl)pyridine-2-carbonitrile / 951753-87-0 / —
Prostate Cancer / O-Phenyl chlorothioformate / Phenyl chlorothionocarbonate / 1005-56-7 / —
Gastrointestinal / Methyl 5-(2,4-difluorophenyl)-4-methoxy-1H-pyrrole-3-carboxylate / 1902955-29-6 / Fexuprazan
Gastrointestinal / (R)-5,7-Difluorochroman-4-ol / 1270294-05-7 / Tegoprazan
Gastrointestinal / 4-Hydroxy-N,N,2-trimethyl-1H-benzo[d]imidazole-6-carboxamide / 2168520-25-8 / —
Gastrointestinal / 4-Hydroxy-N,N,2-trimethyl-1-tosyl-1H-benzo[d]imidazole-6-carboxamide / 942195-86-0 / —
Gastrointestinal / 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde / 881674-56-2 / Vonoprazan Fumarate
Gastrointestinal / Pyridine-3-sulfonyl chloride / 16133-25-8 / —
Gastrointestinal / 4-(Chloromethyl)-1-cyclopentyl-2-(trifluoromethyl)benzene / 957208-65-0 / Etrasimod
Gastrointestinal / 5-Methoxy-1H-benzimidazole-2-thiol / 5-Methoxy-2-mercaptobenzimidazole / 37052-78-1 / Omeprazole
Gastrointestinal / 5-(Difluoromethoxy)-1H-benzimidazole-2-thiol / 97963-62-7 / Pantoprazole
Gastrointestinal / 2-Bromo-1-(3-bromophenyl)ethanone / 3-Bromophenacyl bromide / 18523-22-3 / Tenapanor
Gastrointestinal / 2,2′-(Ethylenedioxy)bis(ethylamine) / 1,8-Diamino-3,6-dioxaoctane / 929-59-9 / —
Gastrointestinal / N-Methyl-2,4-dichlorobenzylamine / 5013-77-4 / —
Cardiovascular / (S)-2-((3-(Methylsulfonyl)phenoxy)methyl)oxirane / 1690064-64-2 / APD418
Cardiovascular / Benzyl (R)-3-amino-1-oxa-8-azaspiro[4.5]decane-8-carboxylate / 2169906-21-0 / —
Cardiovascular / 3-Bromo-2,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one / 86499-96-9 / Benazepril
Cardiovascular / 1-Benzhydrylazetidin-3-ol hydrochloride / 90604-02-7 / Azelnidipine
Cardiovascular / (4-Benzyloxyphenyl)hydrazine hydrochloride / 52068-30-1 / Temanogrel
Cardiovascular / Ethyl 7-bromo-2,2-dimethylheptanoate / 123469-92-1 / Bempedoic Acid
Cardiovascular / 2,1,3-Benzoxadiazole-4-carbaldehyde / 4-Benzofurazancarboxaldehyde / 32863-32-4 / Isradipine
Cardiovascular / 4-(4-Chlorobutyl)pyridine hydrochloride / 149463-65-0 / Tirofiban
Cardiovascular / 3-(4-Methoxyphenoxy)propan-1-amine / 100841-00-7 / Pemafibrate
Cardiovascular / Butyl (2S)-2-hydroxybutanoate / 132513-51-0 / —
Diabetes / Metabolic / 1-Chloro-2-(4-ethoxybenzyl)-4-iodobenzene / 1103738-29-9 / SGLT2 / Gliflozin-class common intermediate
Diabetes / Metabolic / tert-Butyl (R)-piperidin-3-ylcarbamate / (R)-3-(Boc-amino)piperidine / 309956-78-3 / Linagliptin
Diabetes / Metabolic / (R)-3-Aminopiperidine dihydrochloride / 334618-23-4 / Alogliptin
Diabetes / Metabolic / 4-Bromo-7-chloro-6-(4-cyclopropylbenzyl)-2,3-dihydrobenzofuran / 1415477-23-4 / Enavogliflozin / DW16001
Diabetes / Metabolic / 1-Bromo-4-cyclopropylbenzene / 1124-14-7 / —
Diabetes / Metabolic / (4-Chloro-3-(4-ethoxybenzyl)phenyl)((3aS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methanone / 1103738-30-2 / Sotagliflozin
Diabetes / Metabolic / Octadecanedioic acid / 871-70-5 / Semaglutide
Antiviral / 3-Chloro-5-[(2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl)oxy]benzonitrile / 1155846-86-8 / Doravirine
Antiviral / 3-(Chloromethyl)-4-methyl-1H-1,2,4-triazol-5-one / 1338226-21-3 / —
Antiviral / 4-Chloro-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(2,2,2-trifluoroethyl)-1H-indazol-3-amine / 2189684-53-3 / Lenacapavir Sodium
Antiviral / tert-Butyl (S)-(1-(3-bromo-6-(3-methyl-3-(methylsulfonyl)but-1-yn-1-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)carbamate / 2189684-54-4 / —
Antiviral / (S)-1-(3-Bromo-6-(3-methyl-3-(methylsulfonyl)but-1-yn-1-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethan-1-amine / 2375019-85-3 / —
Antiviral / 6-(3-Bromo-5-methylbenzoyl)-5-isopropylpyrimidine-2,4(1H,3H)-dione / 1006300-03-3 / ACC007
Antiviral / 3-Iodo-2-methoxybenzoic acid / 879498-16-5 / Taniborbactam
Antibacterial / Anti-influenza / 1-Cyclopropyl-7-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid / 221221-16-5 / Nemonoxacin
Antibacterial / Anti-influenza / tert-Butyl ((3S,5S)-5-methylpiperidin-3-yl)carbamate / 951163-61-4 / —
Antibacterial / Anti-influenza / 2-(5-Bromopyridin-2-yl)-2,2-difluoro-1-morpholinoethan-1-one / 1809323-20-3 / Oteseconazole
Antibacterial / Anti-influenza / 7,8-Difluoro-6H-benzo[c][1]benzothiepin-11-one / 2136287-66-4 / Pixavir Marboxil / TG-1000
Antibacterial / Anti-influenza / 3-(Benzyloxy)-4-oxo-4H-pyran-2-carbaldehyde / 500371-01-7 / —
Antibacterial / Anti-influenza / Spiro[cyclopropane-1,3′(4′H)-[1H][1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazine]-6′,8′-dione, 12′,12′a-dihydro-7′-(phenylmethoxy)- / 2364588-66-7 / Baloxavir
Antibacterial / Anti-influenza / 1,3-Benzodioxol-5-amine / 3,4-Methylenedioxyaniline / 14268-66-7 / Oxolinic Acid project
Antibacterial / Anti-influenza / Piperidin-4-yl [1,1′-biphenyl]-2-ylcarbamate / 171722-92-2 / Revefenacin
Antibacterial / Anti-influenza / 3,3′-Diaminobenzidine / Biphenyl-3,3′,4,4′-tetramine / 91-95-2 / Ridinilazole
Antiepileptic / Anesthesia / Analgesic / Pyridin-2-ylacetic acid hydrochloride / 2-Pyridylacetic acid hydrochloride / 16179-97-8 / Perampanel
Antiepileptic / Anesthesia / Analgesic / (R)-4-Propyldihydrofuran-2(3H)-one / 63095-51-2 / Brivaracetam
Antiepileptic / Anesthesia / Analgesic / 1-(2-Chlorophenyl)-2-(2H-tetrazol-2-yl)ethan-1-one / 1259059-71-6 / Cenobamate
Antiepileptic / Anesthesia / Analgesic / 2-(2-Amino-5-bromobenzoyl)pyridine / 1563-56-0 / Remimazolam Besylate (API association follows source PPT)
Antiepileptic / Anesthesia / Analgesic / 2-((R)-1-Cyclopropylethyl)-6-isopropylphenyl ((R)-1-phenylethyl)carbamate / 1879080-85-9 / Ciprofol
Antiepileptic / Anesthesia / Analgesic / tert-Butyl 2-{(2-amino-5-fluorophenyl)(methyl)amino}ethylcarbamate / 2097165-02-9 / DWP17061
Antiepileptic / Anesthesia / Analgesic / 4-Bromo-5-chloro-2-fluorobenzenesulfonyl chloride / 1208075-41-5 / —
Antiepileptic / Anesthesia / Analgesic / 4-(Boc-amino)-1-Fmoc-piperidine-4-carboxylic acid / 368866-07-3 / Difelikefalin
Gout / Rheumatology / CNS / Ophthalmic / 1-Cyclopropylnaphthalene / 25033-19-6 / Lesinurad
Gout / Rheumatology / CNS / Ophthalmic / Ethyl 2-bromo-2-ethylbutanoate / 6937-28-6 / HP501
Gout / Rheumatology / CNS / Ophthalmic / 3-(6-Methyl-4,8-dioxo-1,3,6,2-dioxazaborocan-2-yl)benzaldehyde / 1488424-86-7 / Liafensine
Gout / Rheumatology / CNS / Ophthalmic / 2-(Methylamino)-1-(naphthalen-2-yl)ethan-1-ol / 5696-81-1 / —
Gout / Rheumatology / CNS / Ophthalmic / tert-Butyl N-tert-butoxycarbonyl-N-(6-chloropyridazin-3-yl)carbamate / 1198790-66-7 / —
Gout / Rheumatology / CNS / Ophthalmic / 4-Fluoroisoquinoline-5-sulfonyl chloride hydrochloride / 906820-08-4 / Ripasudil
Gout / Rheumatology / CNS / Ophthalmic / tert-Butyl (S)-3-methyl-1,4-diazepane-1-carboxylate / (S)-1-Boc-3-methyl-1,4-diazepane / 194032-32-1 / —
Other Specialty / tert-Butyl 4-(aminomethyl)piperidine-1-carboxylate citrate / 2368870-32-8 / Evobrutinib
Other Specialty / tert-Butyl 4-cyanopiperidine-1-carboxylate / 1-Boc-4-cyanopiperidine / 91419-52-2 / —
Other Specialty / 2-Methylphenyl isothiocyanate / o-Tolyl isothiocyanate / 614-69-7 / Ponesimod
Other Specialty / 2-[3,5-Bis(trifluoromethyl)phenyl]-2-methylpropanoic acid / 289686-70-0 / NT-814
Other Specialty / (3bS,4aR)-5,5-Difluoro-3b,4,4a,5-tetrahydro-3-(trifluoromethyl)-1H-cyclopropa[3,4]cyclopenta[1,2-c]pyrazole-1-acetic acid / 1620056-83-8 / Difelikefalin
Other Specialty / 4-(Boc-amino)-1-Fmoc-piperidine-4-carboxylic acid / 368866-07-3 / —
Other Specialty / Cyclopent-3-ene-1-carboxylic acid / 3-Cyclopentene-1-carboxylic acid / 7686-77-3 / Dolasetron Mesylate
Other Specialty / Hexyl chloroformate / n-Hexyl chloroformate / 6092-54-2 / Dabigatran Etexilate
* Products protected under valid patents are not offered or supplied for commercial use.
This list does not attempt to set out in detail every variant of every product stocked. For comprehensive product listings and specifications, please visit our website [ https://www.aktin.com/en/product/1556 ] or contact our team [ https://www.aktin.com/en/contact ] .
Should you have any inquiries regarding our AkTilin ™ intermediates or CRDMO services, please feel free to get in touch with our team.
Welcome to meet us: CPHI Milan 2026 from Oct. 6-8, Booth No.: 4H109
