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AKA-377
AkProva™ Metildigoxin
Cat. No.
AKA-377
CAS No.
30685-43-9
MF
C42H66O14
MW
794.97
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Description
Documents
Storage and Shipping
References
Product Name
AkProva™ Metildigoxin
CAS No.
30685-43-9
MF
C42H66O14
MW
794.97
Quality specification
JP18
Therapeutic area
Oncology
API Disclaimer
Information provided on generic APIs is for general reference and market assessment purposes only. Regulatory status, market availability, specifications, patents, and commercial conditions may vary by country and change over time. Users should independently verify all information with relevant regulatory authorities and qualified professionals before making regulatory, manufacturing, investment, or commercial decisions. We do not provide products or services to individuals, please strictly comply with all applicable laws, regulations, and the committed use. Use for any other purpose is strictly prohibited.
Description
AkProva™ Metildigoxin is a substrate of the ATP-dependent efflux pump P-glycoprotein. Metildigoxin's polarized transport could be completely inhibited by 1μM PSC-833 Packing: 10mg, 20mg, 50mg, 100mg, 500mg, 1g, 5g, 10g Availability: In stock
Documents
Certificate of Analysis (CoA), API specification, Safety Data Sheet (SDS/MSDS), evidence of GMP compliance, Stability data / stability summary, etc.
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Storage and Shipping
Store in a cool and dry place, avoid strong light and high temperature
References
[1].Funakoshi S, Murakami T, Yumoto R, Kiribayashi Y, Takano M. Role of P-glycoprotein in pharmacokinetics and drug interactions of digoxin and β-methyldigoxin in rats. J Pharm Sci. 2003;92(7):1455-1463. doi:10.1002/jps.10416.
[2].C Pauli-Magnus, et al. P-glycoprotein-mediated transport of digitoxin, alpha-methyldigoxin and beta-acetyldigoxin. Naunyn Schmiedebergs Arch Pharmacol. 2001 Mar;363(3):337-43.
[3].Franzmaier R, inventor; Chemie Linz Aktiengesellschaft, assignee. Process for the preparation of β-methyldigoxin. US patent 4,603,196. July 29, 1986.
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