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AKA-14
Olaparib
Cat. No.
AKA-14
CAS No.
763113-22-0
MF
C24H23FN4O3
MW
434.471
Olaparib is a small molecule inhibitor of PARP1/PARP2, with weak inhibitory activity against PARP tankyrase‑1.
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References
Product Name
Olaparib
CAS No.
763113-22-0
MF
C24H23FN4O3
MW
434.471
Specification
99%
Research Area
Oncology
Description
Olaparib is a small molecule inhibitor of PARP1/PARP2, with weak inhibitory activity against PARP tankyrase‑1. Packing: 1kg/bag; 25kg/drum or as request Availability: In stock
Documents
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Storage and Shipping
Store in a cool & dry place, keep away from strong light and heat.
References
[1]. Menear KA, et al. 4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: a novel bioavailable inhibitor of poly(ADP-ribose) polymerase-1. Journal of Medicinal Chemistry. 2008 Oct 23;51(20):6581-91
[2]. Senra JM, et al. Inhibition of PARP-1 by olaparib (AZD2281) increases the radiosensitivity of a lung tumor xenograft.Molecular Cancer Therapeutics. 2011 Oct;10(10):1949-58.
[3]. Yasukawa M, et al. Synergetic Effects of PARP Inhibitor AZD2281 in Oral Squamous Cell Carcinoma in Vitro and in Vivo. International Journal of Molecular Sciences. 2016 Feb 24;17(3):272.
[4]. Bian X, et al. PTEN deficiency sensitizes endometrioid endometrial cancer to compound PARP-PI3K inhibition but not PARP inhibition as monotherapy. Oncogene. 2018 Jan 18;37(3):341-351.
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