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AKA-29
Cepharanthine
Cat. No.
AKA-29
CAS No.
481-49-2
MF
C37H38N2O6
MW
606.71
Cepharanthine is a natural alkaloid that inhibits TNF‑α‑mediated NFκB stimulation, plasma membrane lipid peroxidation, platelet aggregation and the production of cytokines.
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Product Name
Cepharanthine
CAS No.
481-49-2
MF
C37H38N2O6
MW
606.71
Specification
API
Research Area
Oncology, Anti-infection
Description
Cepharanthine is a natural alkaloid that inhibits TNF‑α‑mediated NFκB stimulation, plasma membrane lipid peroxidation, platelet aggregation and the production of cytokines. Packing: 10g/vial; 100g/bag; 1kg/bag; 5kg/drum or as request Availability: In stock
Documents
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Storage and Shipping
Store in a cool & dry place, keep away from strong light and heat.
References
[1]. Hijikata A, et al. Evaluating cepharanthine analogues as natural drugs against SARS-CoV-2. FEBS Open Bio. 2022;12(1):285-294
[2]. Shen LW, et.al. Cepharanthine sensitizes human triple negative breast cancer cells to chemotherapeutic agent epirubicin via inducing cofilin oxidation-mediated mitochondrial fission and apoptosis. Acta Pharmacologica Sinica. 2022 Jan;43(1):177-193.
[3]. Ikeda R, et.al. Cepharanthine potently enhances the sensitivity of anticancer agents in K562 cells. Cancer Science. 2005 Jun;96(6):372-6.
[4]. Zhang X, et.al. In vitro inhibitory effects of cepharanthine on human liver cytochrome P450 enzymes. Pharmaceutical Biology. 2020 Dec;58(1):247-252.
[5]. Hua P, et.al. Cepharanthine induces apoptosis through reactive oxygen species and mitochondrial dysfunction in human non-small-cell lung cancer cells. Biochemical and Biophysical Research Communications. 2015 May 1;460(2):136-42.
[6]. Desgrouas C, et.al. In vitro antiplasmodial activity of cepharanthine. Malaria Journal. 2014 Aug 22;13:327.
[7]. Murakami K, et.al. The prevention of lipopolysaccharide-induced pulmonary vascular injury by pretreatment with cepharanthine in rats. American Journal of Respiratory and Critical Care Medicine. 2000 Jan;161(1):57-63.
[8]. Wei XY, et,al. Antinociceptive activities and mechanism of action of Cepharanthine. Biochemical and Biophysical Research Communications. 2022 Jul 23;614:219-224.
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