Betuak® Betulinic acid is a natural pentacyclic lupane-type triterpene, an inhibitor of eukaryotic topoisomerase I.
Packing: 1kg/bag; 25kg/drum or as request
Availability: In stock

Store in a cool & dry place, keep away from strong light and heat.

[1]. Chowdhury AR, et al. Betulinic acid, a potent inhibitor of eukaryotic topoisomerase I: identification of the inhibitory step, the major functional group responsible and development of more potent derivatives. Medical Science Monitor. 2002 Jul;8(7):BR254-65. [2]. Gao Y, et al. Betulinic acid induces apoptosis and ultrastructural changes in MDA-MB-231 breast cancer cells. Ultrastructural Pathology. 2018 Jan-Feb;42(1):49-54. [3]. Kalra J, et al. Betulinic acid alleviates dextran sulfate sodium-induced colitis and visceral pain in mice. Naunyn-Schmiedeberg's Archives of Pharmacology. 2017 Dec 26. [4]. Hashimoto F, et al. Anti-AIDS agents--XXVII. Synthesis and anti-HIV activity of betulinic acid and dihydrobetulinic acid derivatives. Bioorganic & Medicinal Chemistry. 1997 Dec;5(12):2133-43. [5]. Kasperczyk H, et al. Betulinic acid as new activator of NF-kappaB: molecular mechanisms and implications for cancer therapy. Oncogene. 2005 Oct 20;24(46):6945-56. [6]. Fernandes S, et al. Betulinic Acid for Glioblastoma Treatment: Reality, Challenges and Perspectives. International Journal of Molecular Sciences. 2024 Feb 9;25(4):2108.