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AKA-317
(+)-Cinchonine
Cat. No.
AKA-317
CAS No.
118-10-5
MF
C19H22N2O
MW
294.4
Cinchonine is a natural compound.
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Description
Documents
Storage and Shipping
References
Product Name
(+)-Cinchonine
CAS No.
118-10-5
MF
C19H22N2O
MW
294.4
Specification
98%
Research Area
Cinchonine, a quinoline-type alkaloid extracted from cinchona bark, primarily exhibits antimalarial and antipyretic biological activities, with recent studies indicating its ability to promote tumor cell apoptosis. As both an antimalarial agent and a catalyst in asymmetric synthesis, this compound is widely utilized in pharmaceuticals and organic synthesis, often employed in the preparation of antitumor drugs.
Disclaimer
This product is intended solely for scientific research or regulatory filing purposes. We do not provide products or services to individuals, please strictly comply with all applicable laws, regulations, and the committed use. Use for any other purpose is strictly prohibited.
Description
Cinchonine is a natural compound. Packing: 1kg/bag; 25kg/drum or as request Availability: In stock
Documents
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Storage and Shipping
Store sealed, protected from light, at 2-8°C.
References
[1]. Qi Y, et al. Cinchonine induces apoptosis of HeLa and A549 cells through targeting TRAF6. Journal of Experimental & Clinical Cancer Research. 2017 Feb 23;36(1):35.
[2]. Jin ZL, et al. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells. Experimental and Therapeutic Medicine. 2018 Jun;15(6):5046-5050.
[3]. Wang H, et al. Cinchonine exerts anti-tumor and immunotherapy sensitizing effects in lung cancer by impairing autophagic-lysosomal degradation. Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie. 2023 Aug;164:114980.
[4]. Jung SA, et al. Cinchonine Prevents High-Fat-Diet-Induced Obesity through Downregulation of Adipogenesis and Adipose Inflammation. PPAR Research. 2012;2012:541204.
[5]. Jo YJ, et al. Cinchonine inhibits osteoclast differentiation by regulating TAK1 and AKT, and promotes osteogenesis. Journal of Cellular Physiology. 2021 Mar;236(3):1854-1865.
[6]. Shah BH, et al. The inhibitory effect of cinchonine on human platelet aggregation due to blockade of calcium influx. Biochemical Pharmacology. 1998 Oct 15;56(8):955-60.
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