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AKA-314
7alpha-Hydroxycholesterol
Cat. No.
AKA-314
CAS No.
566-26-7
MF
C27H46O2
MW
402.663
7α-Hydroxycholesterol is a cholesterol oxide and can serve as a biomarker for oxidative stress and lipid peroxidation.
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Description
Documents
Storage and Shipping
References
Product Name
7alpha-Hydroxycholesterol
CAS No.
566-26-7
MF
C27H46O2
MW
402.663
Specification
98%
Research Area
7 α-Hydroxycholesterol is a key metabolic precursor in the conversion of cholesterol to bile acids in animals. It is primarily catalyzed by cholesterol 7α-hydroxylase (CYP7A1) and constitutes the rate-limiting step in bile acid synthesis.
Disclaimer
This product is intended solely for scientific research or regulatory filing purposes. We do not provide products or services to individuals, please strictly comply with all applicable laws, regulations, and the committed use. Use for any other purpose is strictly prohibited.
Description
7α-Hydroxycholesterol is a cholesterol oxide and can serve as a biomarker for oxidative stress and lipid peroxidation. Packing: 10mg, 20mg, 50mg, 100mg, 500mg, 1g, 5g, 10g, 1kg Availability: In stock
Documents
Can't find the right version? Our team of experienced experts is here for you with full support.Contact Us
Storage and Shipping
Store under nitrogen, protected from light, in a tightly sealed container, refrigerated or frozen.
References
[1]. Nury T, et al. Improved synthesis and in vitro evaluation of the cytotoxic profile of oxysterols oxidized at C4 (4α- and 4β-hydroxycholesterol) and C7 (7-ketocholesterol, 7α- and 7β-hydroxycholesterol) on cells of the central nervous system. European Journal of Medicinal Chemistry. 2013;70:558-67.
[2]. Kandutsch AA, et al. Inhibition of sterol synthesis in cultured mouse cells by 7alpha-hydroxycholesterol, 7beta-hydroxycholesterol, and 7-ketocholesterol. The Journal of Biological Chemistry. 1973 Dec 25;248(24):8408-17.
[3]. Son Y, et al. Glucocorticoids Impair the 7α-Hydroxycholesterol-Enhanced Innate Immune Response. Immune Network. 2023 Oct 19;23(5):e40.
[4]. Ferderbar S, et al. Cholesterol oxides as biomarkers of oxidative stress in type 1 and type 2 diabetes mellitus. Diabetes/metabolism Research and Reviews. 2007 Jan;23(1):35-42.
[5]. Kitano S, et al. Oxidative status of human low density lipoprotein isolated by anion-exchange high-performance liquid chromatography--assessment by total hydroxyoctadecadienoic acid, 7-hydroxycholesterol, and 8-iso-prostaglandin F(2alpha). Analytica Chimica Acta. 2007 Feb 28;585(1):86-93.
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