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AKA-304
Esculetin
Cat. No.
AKA-304
CAS No.
305-01-1
MF
C9H6O4
MW
178.14
Esculetin is an active ingredient extracted mainly from the bark of Fraxinus rhynchophylla.
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Description
Documents
Storage and Shipping
References
Product Name
Esculetin
CAS No.
305-01-1
MF
C9H6O4
MW
178.14
Specification
98%
Research Area
6,7-Dihydroxycoumarin (also known as esculetin or aesculetin) is an important pharmaceutical intermediate, primarily used for the synthesis of the antiasthmatic drug dimethoxycoumarin. It possesses notable pharmacological activities, including antibacterial, antiasthmatic, expectorant, and antitussive effects, particularly demonstrating inhibitory activity against Shigella species. Clinically, it is commonly used in the treatment of acute bacillary dysentery and chronic bronchitis.
Disclaimer
This product is intended solely for scientific research or regulatory filing purposes. We do not provide products or services to individuals, please strictly comply with all applicable laws, regulations, and the committed use. Use for any other purpose is strictly prohibited.
Description
Esculetin is an active ingredient extracted mainly from the bark of Fraxinus rhynchophylla. Packing: 1kg/bag; 25kg/drum or as request Availability: In stock
Documents
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Storage and Shipping
Store sealed, protected from light, at 2-8°C.
References
[1]. Xie C, et al. Esculetin regulates the phenotype switching of airway smooth muscle cells. Phytotherapy Research. 2019 Aug 21.
[2]. Arora R, et al. Esculetin induces antiproliferative and apoptotic response in pancreatic cancer cells by directly binding to KEAP1. Molecular Cancer. 2016 Oct 18;15(1):64.
[3]. Chen Y, et al. Esculetin Ameliorates Psoriasis-Like Skin Disease in Mice by Inducing CD4+Foxp3+ Regulatory T Cells. Frontiers in Immunology. 2018 Sep 12;9:2092.
[4]. Kim WK, et al. Esculetin suppresses tumor growth and metastasis by targeting Axin2/E-cadherin axis in colorectal cancer. Biochemical Pharmacology. 2018 Jun;152:71-83.
[5]. Martín-Aragón S, et al. Age-dependent effects of esculetin on mood-related behavior and cognition from stressed mice are associated with restoring brain antioxidant status. Progress in Neuro-psychopharmacology & Biological Psychiatry. 2016 Feb 4;65:1-16.
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