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AKA-127
7-Ethyl-10-hydroxycamptothecin
Cat. No.
AKA-127
CAS No.
86639-52-3
MF
C22H20N2O5
MW
392.4046
SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan.
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References
Product Name
7-Ethyl-10-hydroxycamptothecin
CAS No.
86639-52-3
MF
C22H20N2O5
MW
392.4046
Specification
98%
Research Area
Intermediate
Description
SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. Packing: 1kg/bag; 25kg/drum or as request Availability: In Stock
Documents
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Storage and Shipping
Store in a cool & dry place, keep away from strong light and heat.
References
[1]. Wallin A, et al. Anticancer effect of SN-38 on colon cancer cell lines with different metastatic potential. Oncology Reports. 2008;19(6):1493-1498.
[2]. Jensen NF, et al. Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a new pair of resistance-associated mutations. Journal of Experimental & Clinical Cancer Research. 2016;35:56.
[3]. Kawato Y, et al. Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11. Cancer Research. 1991;51(16):4187-4191.
[4]. Jacobs AT, et al. Targeted therapy for breast cancer: An overview of drug classes and outcomes. Biochemical Pharmacology. 2022;204:115209.
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