Higenamine hydrochloride is a selective LSD1 inhibitor.
Packing: 1kg/bag; 25kg/drum or as request
Availability: In Stock

Store in a cool & dry place, keep away from strong light and heat.

[1]. Fang Y, et al. Discovery of higenamine as a potent, selective and cellular active natural LSD1 inhibitor for MLL-rearranged leukemia therapy. Bioorganic Chemistry. 2021;109:104723. [2]. Ha YM, et al. Higenamine reduces HMGB1 during hypoxia-induced brain injury by induction of heme oxygenase-1 through PI3K/Akt/Nrf-2 signal pathways. Apoptosis. 2012;17(5):463-474. [3]. Zhu X, et al. Higenamine mitigates interleukin-1β-induced human nucleus pulposus cell apoptosis by ROS-mediated PI3K/Akt signaling. Molecular and Cellular Biochemistry. 2021;476(11):3889-3897. [4]. Deng T, et al. Higenamine Improves Cardiac and Renal Fibrosis in Rats With Cardiorenal Syndrome via ASK1 Signaling Pathway. Journal of Cardiovascular Pharmacology. 2020;75(6):535-544. [5]. Erasto P, et al. Evaluation of Antimycobacterial Activity of Higenamine Using Galleria mellonella as an In Vivo Infection Model. Natural Products and Bioprospecting. 2018;8(1):63-69. [6]. Dong H, et al. Higenamine Promotes Osteogenesis Via IQGAP1/SMAD4 Signaling Pathway and Prevents Age- and Estrogen-Dependent Bone Loss in Mice. Journal of Bone and Mineral Research. 2023;38(5):775-791.