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AKA-75
Pomalidomide
Cat. No.
AKA-75
CAS No.
19171-19-8
MF
C13H11N3O4
MW
273.24
Pomalidomide, the third-generation immunomodulatory agent, acts as molecular glue.
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Product Name
Pomalidomide
CAS No.
19171-19-8
MF
C13H11N3O4
MW
273.24
Specification
98%
Research Area
Intermediate
Description
Pomalidomide, the third-generation immunomodulatory agent, acts as molecular glue. Packing: 10mg, 20mg, 50mg, 100mg, 500mg, 1g, 5g, 10g, 1kg Availability: In Stock
Documents
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Storage and Shipping
Store in a cool & dry place, keep away from strong light and heat.
References
[1]. Zhu YX, et al. Molecular mechanism of action of the immune-modulatory drugs, thalidomide, lenalidomide and pomalidomide in multiple myeloma. Leukemia & Lymphoma. 2013 Apr;54(4):683-7.
[2]. Hernandez-Ilizaliturri FJ, et al. Immunomodulatory drug CC-5013 or CC-4047 and rituximab enhance antitumor activity in a severe combined immunodeficient mouse lymphoma model. Clinical Cancer Research. 2005 Aug 15;11(16):5984-92.
[3]. Schafer PH, et al. Enhancement of cytokine production and AP-1 transcriptional activity in T cells by thalidomide-related immunomodulatory drugs. The Journal of Pharmacology and Experimental Therapeutics. 2003 Jun;305(3):1222-32.
[4]. Li Z, et al. Pomalidomide shows significant therapeutic activity against CNS lymphoma with a major impact on the tumor microenvironment in murine models. PloS One. 2013 Aug 5;8(8):e71754.
[5]. Lu J, et al. Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4. Chemistry & Biology. 2015 Jun 18;22(6):755-63.
[6]. Liu D, et al. Tumour necrosis factor-α inhibits hepatic lipid deposition through GSK-3β/β-catenin signaling in juvenile turbot (Scophthalmus maximus L.). General and Comparative Endocrinology. 2016 Mar 1;228:1-8.
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