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AKA-53
Camptothecin
Cat. No.
AKA-53
CAS No.
7689-03-4
MF
C20H16N2O4
MW
348.352
Camptothecin, a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor.
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Description
Documents
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References
Product Name
Camptothecin
CAS No.
7689-03-4
MF
C20H16N2O4
MW
348.352
Specification
98%
Research Area
Intermediate
Description
Camptothecin, a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor. Packing: 1kg/bag; 25kg/drum or as request Availability: In Stock
Documents
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Storage and Shipping
Store in a cool & dry place, keep away from strong light and heat.
References
[1]. Luzzio MJ, et al. Synthesis and antitumor activity of novel water soluble derivatives of camptothecin as specific inhibitors of topoisomerase I. Journal of Medicinal Chemistry. 1995 Feb;38(3):395-401.
[2]. Bertozzi D, et al. The natural inhibitor of DNA topoisomerase I, camptothecin, modulates HIF-1α activity by changing miR expression patterns in human cancer cells. Molecular Cancer Therapeutics. 2014 Jan;13(1):239-248. PMID: 24252850
[3]. Huang Q, et al. Evolution in medicinal chemistry of E-ring-modified Camptothecin analogs as anticancer agents. European Journal of Medicinal Chemistry. 2013;63:746-757.
[4]. Tesauro C, et al. Topoisomerase I activity and sensitivity to camptothecin in breast cancer-derived cells: a comparative study. BMC Cancer. 2019 Nov 29;19(1):1158.
[5]. Schön M, et al. KINK-1, a novel small-molecule inhibitor of IKKbeta, and the susceptibility of melanoma cells to antitumoral treatment. Journal of the National Cancer Institute. 2008;100(12):862-875.
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