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AKA-35
Thalidomide
Cat. No.
AKA-35
CAS No.
50-35-1
MF
C13H10N2O4
MW
258.23
Thalidomide binds to the DDB1-CRBN E3 ubiquitin ligase complex.
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Product Name
Thalidomide
CAS No.
50-35-1
MF
C13H10N2O4
MW
258.23
Specification
99%
Research Area
Intermediate
Description
Thalidomide binds to the DDB1-CRBN E3 ubiquitin ligase complex. Packing: 1kg/bag; 25kg/drum or as request Availability: In Stock
Documents
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Storage and Shipping
Store in a cool & dry place, keep away from strong light and heat.
References
[1]. Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53. PMID: 25043012
[2]. Sun X, et al. Synergistic Inhibition of Thalidomide and Icotinib on Human Non-Small Cell Lung Carcinomas Through ERK and AKT Signaling. Medical Science Monitor. 2018 May 15;24:3193-3203. PMID: 29763936
[3]. Bian C, et al. Thalidomide (THD) alleviates radiation induced lung fibrosis (RILF) via down-regulation of TGF-β/Smad3 signaling pathway in an Nrf2-dependent manner. Free Radical Biology & Medicine. 2018 Dec;129:446-453. PMID: 30339882
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